International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 1, Issue 5 (2015)

Implications for the modulation of angiogenesis


Peter Pressman, Dr. Roger A Clemens

While there has been much recent work addressing the association of the mammalian gut microbiome with pro-angiogenesis in the small bowel, speculation involving putative/discrete tumor promoting angiogenins seems notably immature, even absent. There is certainly abundant discussion involving the cascade of pro-inflammatory cytokines, chronic inflammation, cell growth factors, toxic bacterial metabolites, and their interaction with components of the immune system, but there seems a paucity of research on induction of endothelial proliferation and the potential clinical use of natural or synthetic angiogenic inhibitors. While Bevacizumab has been approved as an angiogenesis targeted therapy in colorectal lung, and renal cell cancer, and in glioblastoma (in conjunction with other therapies), its clinical efficacy to date appears dubious. We view this observation as further rationale for future bold investigation into the isolation of specific bacterial angiogenins and readily synthesized antibodies directed against them.
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