International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 2, Issue 2 (2016)

To evaluate HS-CRP and Osteoprotegerin as risk factors in acute coronary syndrome in patients of type 2 DM


Dr. Subhash Chandra Bj, Basireddy Haripriya

Background: Osteoprotegerin (OPG), a key factor in vascular calcification and atherosclerosis has been suggested to be associated with cardiovascular events particularly in patients with Type 2 DM. This study sought to assess the relationship between Osteoprotegerin and hs-CRP with other conventional cardiovascular disease risk factors in Type 2 Diabetes Mellitus patients. 
Methods: A total of 80 consecutive type 2 diabetes mellitus patients with symptoms of acute coronary syndrome were enrolled in this cross-sectional study. They were divided into two groups each with reference to age, Group A (40-60yr), Group B (>60yr). Blood samples were taken for laboratory tests. OPG, hs-CRP and other conventional risk factors were measured.
Results: OPG levels were in direct association with smoking (p=0.046), STEMI (mean-7.33 ng/ml) and inversely related to age (Group A>B; p=0.02). Hs-CRP level was in direct association with STEMI and low ejection fraction (%). After adjusting for variables like Hb, ESR and total cholesterol (p=0.048) was significant indicator of hs-CRP. Total cholesterol (p=0.002) has direct linear association with acute coronary syndrome. Serum hs-CRP and serum OPG in type 2 diabetic patients were not associated (p>0.05) with the conventional risk factors like alcohol abuse, duration of diabetes, BMI, waist circumference and HbA1C.
Conclusion: Increased levels of OPG is associated with smoking and in patients with STEMI. Severe LV systolic dysfunction was observed in patients with high hs-CRP levels and mild LV systolic dysfunction in patients with high OPG levels.
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