Osteoprotegerin (OPG), a key factor in vascular calcification and atherosclerosis has been suggested to be associated with cardiovascular events particularly in patients with Type 2 DM. This study sought to assess the relationship between Osteoprotegerin and hs-CRP with other conventional cardiovascular disease risk factors in Type 2 Diabetes Mellitus patients.
Methods: A total of 80 consecutive type 2 diabetes mellitus patients with symptoms of acute coronary syndrome were enrolled in this cross-sectional study. They were divided into two groups each with reference to age, Group A (40-60yr), Group B (>60yr). Blood samples were taken for laboratory tests. OPG, hs-CRP and other conventional risk factors were measured.
Results: OPG levels were in direct association with smoking (p=0.046), STEMI (mean-7.33 ng/ml) and inversely related to age (Group A>B; p=0.02). Hs-CRP level was in direct association with STEMI and low ejection fraction (%). After adjusting for variables like Hb, ESR and total cholesterol (p=0.048) was significant indicator of hs-CRP. Total cholesterol (p=0.002) has direct linear association with acute coronary syndrome. Serum hs-CRP and serum OPG in type 2 diabetic patients were not associated (p>0.05) with the conventional risk factors like alcohol abuse, duration of diabetes, BMI, waist circumference and HbA1C.
Conclusion: Increased levels of OPG is associated with smoking and in patients with STEMI. Severe LV systolic dysfunction was observed in patients with high hs-CRP levels and mild LV systolic dysfunction in patients with high OPG levels.