International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 2, Issue 2 (2016)

Skeletal abnormalities induced by antimalarial drug alpha/beta artether on developing chick embryo


Lavlesh Kumar Mittal, Vishram Singh, Ashoka RK, Garg AK, SushmaTomar, Abhibhushan Mishra, Ghazal Mittal

Since a long time chick embryo is proving a satisfactory animal for embryological research work due to several advantages as eggs of chick are large in size, can be incubated artificially and are easy to control. Malaria a febrile infection caused by protozoa Plasmodium and spread by female anopheles mosquito still continues to be one of the India’s leading public health problem. In the south-east Asia approximately 1.2 billion population are presented to the danger of malaria and majority of whom live in India. α/β artether is one of the most common antimalarial drug used worldwide to treat chloroquine resistant malaria and malaria falciparum. The present study was designed to assess the effects of α/β artether on developing chick embryo. The study was conducted in the Department of Anatomy, Santosh Medical College, Santosh Nagar, Ghaziabad U.P. in association with. Department of Anatomy, Gold Field Institute of Medical Sciences And Research, village Chhainsa, Ballabgarh, Faridabad, Haryana. The study was performed on 300 fertilized eggs of white leg horn chicken. The eggs were divided in to five experimental groups A, B, C, D, E having 50 eggs each and five control groups a, b, c, d, e one each for every control group respectively and having 10 eggs each. On 5th day of incubation eggs from experimental groups A, B, C, D and E were exposed to α/β artether with doses of 0.12mg, 0.24mg, 0.36 mg, 0.48mg and 0.60mg in volume of 0.04ml, 0.08ml, 0.12ml, 0.16ml, and 0.20ml respectively. Whereas the control groups were treated with same amount of normal saline. On 20th day of incubation the eggs were broken and embryos were removed. The results showed growth retardation and some significant morphological and skeletal abnormalities.
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