International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 2, Issue 3 (2016)

Recent advances in molecular pathogenesis of multiple myeloma – Role of cytokine: Review of literature


Dr. Lohit kumar Kalita, Dr. Bhubaneswar saikia

There is a growing body of evidence that a network of cytokines is involved in the growth, progression, and dissemination of multiple myeloma. Some are actually produced by the malignant plasma cells including interleulkin-1 beta (IL-1β) tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF), and a functionally active truncated version of macrophage colony-stimulating factor (M-CSF). These and other cytokines act as mediators of tumor cell growth, survival, migration, and development of drug resistance.
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