International Journal of Medical and Health Research


ISSN: 2454-9142

Vol. 2, Issue 3 (2016)

Prolonged Administration of Various Calcium Channel Blocker Drugs Jeopardizes the Homeostasis of Our Body, Though They Are Life Saving

Author(s): Partha Majumder, Anjana Mazumder, Amitabha Kar, Sufal Halder
Abstract: In this paper, our study sought to clarify some factors that describe a comprehensive approach of a biofeedback paying regards to homeostasis of human body. A biofeedback system involves a sensory organ and an appropriate stimulus. The stimulus is mediated through organs derived from specific biosensors. Homeostasis is the set of processes by which constant or static conditions are maintained within the internal environment of a of a subject and therefore a homeostat is a controller involved in maintaining homeostasis. Calcium channel blockers are a class of drugs and natural substances with effects on many excitable cells of the body, like the muscles of the heart, smooth muscles of the vessels or neuron cells. The main action of the Calcium channel blockers is to reduce the blood pressure. It is for this action that it is used in individuals with hypertension. Most important fact is that, sodium ions are also driving force in Antiports that extrude Calcium ions from a variety of cells. The Sodium-Calcium exchanger sends Calcium ion out of the cell in exchange for the entry of three Sodium ions. This Antiporter is extremely important in maintaining the cytosolic Calcium ion level in many cells of our body. So, Calcium channel blocker drugs, though they are lifesaving, but prolonged administration of those drugs jeopardizes homeostasis of our body with the development of several side effects like dizziness, headache, fluid deposition in limbs, constipation and impaired reflex in vasoconstriction as well as vasorelaxation. Though now-a-days, several diuretic drugs are used simultaneously with those hypertensive drugs to avoid deposition of fluids in the body, but such sort of concept as well as practice fails to give relief to a patient from impaired vasorelaxation which in turn may develop several chronic disorders associated with vasoconstriction in different parts of our body.
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