International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 2, Issue 5 (2016)

Original Research article: A Study of Serum Bilirubin as a Marker of Oxidative Stress in Hypertensive and Normotensive Subjects


Shweta Biyani, Rajul Lodha, Renuka Z Lal

Background: Oxidative stress is found to be one of the causes of hypertension. Serum Bilirubin is found to be an antioxidant and participates in defense mechanism against oxidative stress.rnAims & Objectives: To see relation between serum bilirubin and hypertension along with MDA (Malondialdhyde).rnMethodology: In the present study serum MDA and Serum bilirubin was measured in 25 patients with hypertension and 25 normotensive healthy adults showing family history of CAD.rnResults: The mean concentration of S.bilirubin (mg/dl) in hypertensive study group is 1.13±0.2 and that of control group is 0.56±0.3. The mean concentration of S.MDA (mmol/L) in hypertensive study group is 5.1±1.3 and that of control group is 1.5±1.1.rnConclusion: The subjects with higher bilirubin level showed a lower incidence of hypertension than did the subjects with lower bilirubin level. In humans, the effects of mildly increased serum bilirubin levels have been reported to be a decreased risk for the development of coronary artery disease and atherosclerosis.
Graphical presentation of the Mean concentration of S. Bilirubin and S.MDA in test and control Group
Fig.: Graphical presentation of the Mean concentration of S. Bilirubin and S.MDA in test and control Group
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