In Vitro investigation on antimicrobial sensitivity pattern of enteric fever causing bacteria isolated from different clinical sources in Dhaka City, Bangladesh
Sajan Das, Mohammad Shahriar, Syeda Najah Narjish, Rumana Akhter
Background: Enteric fever continues to remain a major public health problem, especially in Dhaka city, Bangladesh due to poor sanitation and water supply as well as self medication. In this study we evaluate the prevalence and antibiotic sensitivity pattern of Salmonella typhi and Salmonella paratyphi isolates.
Methods: A total of 106 clinical isolates were collected and processed and identified by standard microbiological method and biochemical tests and antimicrobial susceptibility testing was carried out by a standard disc diffusion method.
Result: Out of all clinical isolates 83.49% of these isolates were Salmonella typhi and 16.50% were Salmonella paratyphi A.Salmonella typhi was found to be most sensitive to levofloxacin, aztreonam, imipenam and less sensitive to ciprofloxacin (25.58%), azithromycin (27.9%), amoxyclav (37.2%). Salmonella paratyphi A was found to be most sensitive to ceftriaxone, levofloxacin, aztreonam, cefixime, gatifloxacin, imipenam and showed least sensitive to azithromycin (23.53%), ciprofloxacin (29.41%). Overall 44.7% (n= 46) of the isolates were multidrug-resistant.
Conclusion: This study suggests the further monitoring of efficacy of older and newer antimicrobial agents for the proper treatment and management of enteric fever.