Modulation of oxidant: Antioxidant imbalance by Hygrophila Auriculata (K. Schum) heine in mercuric chloride induced oxidative stress in rat liver
Dr. Sridhar MP, Dr. Geetha R, Anitha D, Muthukumar R, Dr. Ramesh V
The deleterious effect of mercury has been attributed to mercury induced oxidative stress with the consequence of lipid peroxidation. The present study was designed to investigate the effect of ethanolic extract of Hygrophila auriculata on mercury induced oxidative damage in rat liver. Mercuric chloride (HgCl2) (1mg/kg b.w, i.p) was administered three times in a week for two weeks to induce mercury toxicity. Mercury damage to the liver was evident from increase in the activity of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and acid phosphatase (ACP) in serum. The level of lipid peroxidation (LPO) was increased in liver tissue along with decrease in both the enzymatic and non-enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin C and vitamin E. Post treatment with ethanolic extract of Hygrophila auriculata (100 mg/kg b.w, p.o) for 10 days after mercury induction completely ameliorated the mercury induced oxidative damage.