Vol. 2, Issue 8 (2016)
Comparison of urinary hCG and recombinant hCG during ovulation induction in intrauterine insemination cycles; a clinical trial
Author(s): Forough Forghani, Azizeh Ghaseminegad, Ozra Azmoodeh, Mohamadpour
Abstract: Objective: to compare urinary human chorionic gonadotropin (uhCG) and recombinant human chorionic gonadotropin (rhCG) during ovulation induction in intrauterine insemination (IUI) cycles in infertile women. Materials and Methods: In this randomized clinical trial, we evaluated 385 healthy women (428 cycles) aged between 20 and 44 years undergoing controlled ovarian hyper stimulation-intrauterine insemination (COH-IUI) cycles in Zanan Hospital, Tehran, Iran, from 2010 to 2011. The patients were randomized into two groups before starting the cycle. Group 1 (n =224) received uhCG, while group 2 (n =204) received rhCG. Then two groups were compared regarding the rate of ovulation and pregnancy Results: We evaluated 385 women (428 COH-IUI cycles), and showed that the pregnancy rate in uhCG group was higher than rhCG group(28.6% vs.27.5%),butthedifference between two groups was not significant(p=0.965).Sixdays after hCG injection, progesterone level (P4≥3 ng/ml) (ovulation rate) in uhCG group was higher than rhCG group (93% vs. 88.6% ), but the differences between two groups were not significant (p = 0.19).The differences between two groups regarding the type of infertility, duration of infertility, the cause of infertility and age were not significant (p>0.05). Conclusion: Our finding confirmed that rhCG and uhCG did not show significant difference regarding ovulation and pregnancy rates in intrauterine insemination cycles in infertile women. Furthermore, our results indicated that age, duration of infertility and cause of infertility did not impact the outcome of treatment.