International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 2, Issue 8 (2016)

Chemometric based classification study on omega-3 fatty acids in psychotic disorders: schizophrenia, major depressive disorder and suicide attempted


Hamidreza Jamilian, Mahmoud Gharbavi, Homayoun Sheikholeslami, Mohammadreza Khansari

Background and aim: It is supposed that omega-3 fatty acids impacts on psychiatric disorders, in this study we evaluated the impact of erythrocyte omega-3 fatty acids compositions on psychotic disorders: schizophrenia, major depressive disorder and suicide attempted using chemometric based classification

Materials and Methods: In 125 patients with schizophrenia, major depressive disorder, suicide attempted and healthy control, we used Varian gas chromatography instrument, utilizing an omega wax 250 capillary column (30m× 0.25mm I.D.) and flame ionization detector to measure erythrocyte membrane n-3PUFAs composition and analyzed based chemometric classification

Results: 125 patients (51 male, 74 female) more than 15 were evaluated. In the control group the level of n-3 PUFA and subtypes of n-3 PUFA significantly was more than other groups. Correlations between subtypes 22:6n-3(DHA), 20:5n-3(EPA), 22:5n-3 and Beck Depression Inventory scale (BDIS) was significant. This study compares results obtained with chemometric methods: SIMCA and PLS-DA. The PLS-DA prediction was better than SIMCA in MDD and suicide attempted. In both techniques, the prediction rate for schizophrenia was 100%.

Conclusion: We revealed the level of erythrocyte omega-3 fatty acids compositions in patients with schizophrenia, major depressive disorder and suicide attempt was lower than healthy population, moreover regarding chemometric methods, PLS-DA was slightly better than SIMCA.

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