Vol. 3, Issue 1 (2017)
A study on lymphocytic and collagenous colitis (microscopic colitis)
Author(s): Dr. Gaurav Pandey, Dr. Supriya Sharma, Dr. Seema Choudhary, Dr. Arvind Kumar Choudhary, Dr. Sushma Pandey
Abstract: Microscopic colitis is a chronic, inflammatory disease of the colon that is characterized by chronic, watery non bloody diarrhea. The diarrhea usually does not contain blood of pus. It typically occurs in middle-aged patients and has a female preponderance. The colon appears normal on colonoscopy or, sigmoidoscopy, radiographically in patients with microscopic colitis. The diagnosis is established by biopsy of the colonic mucosa. The collagenous colitis was described concurrently in 1976 by Lindstrom and by Freeman. In 1980, Read described microscopic colitis, which is clinically indistinguishable from CC but is differentiated from it by specific biopsy features. later, the term LC was proposed by Lazenby to replace the microscopic colitis and to distinguish it from infectious colitis and inflammatory bowel disease, The estimated incidence of collagenous colitis and lymphocytic colitis are 1.1 to 5.2 and 3.1 to 5.5 per 100, 000 per year, respectively. The disease has been increasingly diagnosed over many years but it is still uncommon. The mean age at diagnosis of microscopic colitis is approximately 65 years. However, approximately 25 percent of patients with microscopic colitis are diagnosed before the age of 45 years. Although microscopic colitis has been reported in children, it is rare. Microscopic colitis has a female preponderance, which appears to be more pronounced in collagenous as compared with lymphocytic colitis.