Vol. 3, Issue 12 (2017)
A study on blood urea and serum creatinine in diabetes mellitus from Sangareddy District, Telangana, India
Author(s): Dr. Madhusudan Rao Sirivole MD, Sadhvimani Eturi
Abstract: This study was conducted in the Department of Biochemistry, M.N.R. Medical College, Sangareddy District, Telangana, India, comprising of n=50 subjects known Diabetes mellitus patients with age range 40 - 55 years and n=25 healthy controls age range 40 - 52 yrs. The study was aimed to quantitatively estimate the amount of blood sugar, urea and creatinine levels present in the blood serum, and evaluate their correlation in diabetic and non-diabetic subjects; also compare the variation in blood urea and serum creatinine levels in relation to blood sugar levels. The mean and Standard deviation of blood sugar fasting and post prandial in controls was 92.76 ± 11.18 and 126.24 ± 7.24 respectively, whereas in diabetics it was found to be 175.28 ± 32.45 and 263.04 ± 44.27 respectively. The statistical analysis data showed that the mean fasting and post prandial blood sugar levels are significantly (p < 0.000) higher in the diabetic subjects compared to non-diabetic controls. The mean (± S.D) values of blood urea in non-diabetic control group was observed to be 25.36 ± 3.47, whereas in diabetic patients 58.84 ± 14.39. The mean (±S.D) serum creatinine levels in healthy controls was 0.88 ± 0.14 and in diabetics 1.839 ± 0.80. Thus, the mean blood sugar, blood urea and serum creatinine levels were significantly (p≤0.05) higher in the diabetic subjects compared to controls. Sex wise blood sugar level status and renal function parameters viz., blood urea and serum creatinine in diabetic subjects was significantly higher in male over female subjects. Strong relationship of blood urea and serum creatinine levels was found with blood sugar levels. Blood urea and serum creatinine levels along with blood glucose levels would be helpful to monitor the diabetes patients to assess renal function.