Vol. 3, Issue 2 (2017)
Triple negative breast cancer: A therapeutic challenge
Author(s): Dr. G Suryanarayana Raju, Dr. Rajshekar Shantappa, Dr. Shubhranshu Jena
Abstract: Triple negative breast cancer (TNBC) is special subgroup of breast cancer accounting for 15-25%, with clinico-pathological heterogenesity, aggressive course and limited treatment options making clinical management challenging as they lack benefit of specific targeted therapy. The aim was to study the incidence, clinico-pathological characteristics and treatment outcomes of TNBC’s at our institute. We have reviewed 65 cases of TNBC operated between 2005-2010. Their clinical presentations, pathological and immunohistochemistry features were studied and their correlations with recurrences were reviewed. Most of the patients had grade 3 histology (53.8%) particularly patients under 50 years (65.7%). There were 14 recurrences (21.5%); Most of the recurrent cases were grade 3(9/14) and lymphnode positive (11/14). 13 patients had undergone chemotherapy and 8 had radiotherapy also as part of initial treatment. 12 patients had distant metastasis (85.7%) and 2 had local recurrences (14.2%). Triple negative breast cancers have aggressive course with susceptibility for visceral metastasis, with poor prognosis inspite of chemotherapy.
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