Vol. 3, Issue 2 (2017)
Antihyperglycemic and antihyperlipidemic activity of ethanol extract of garlic (Allium sativum) in streptozotocin-induced diabetic mice
Author(s): Mamun MA, Hasan N, Shirin F, Belal MH, Khan MAJ, Tasnin MN, Islam MD, Islam A, Ara T, Karim MRU, Rahman KZ, Rahman MM, Khan MMH, Karim MR, Islam MA
Abstract: The present study was conducted to evaluate the hypoglycemic and hypolipidemic effects of ethanol extract of Allium sativum (EEAS) locally grown in Bangladesh. Male Swiss albino mice were divided into four groups as normal control, diabetic control, EEAS-treated and glibenclamide-treated diabetic mice. Diabetes was induced in mice by intraperitoneal administration of streptozotocin (50mg/kg of body weight) and treatment was started 14 days after diabetes induction. In extract-treated mice, EEAS was orally given at a dose of 200mg/kg for 28 days and its effect on blood glucose level and body weight was determined on a weekly basis. On completion of the treatment, fasting blood sample was collected to estimate a range of indicators including blood lipid profile, serum glutamate-oxaloacetate transaminase (SGOT) and serum glutamate-pyruvate transaminase (SGPT). Oral administration of EEAS in diabetic mice resulted in significant (P<0.01 to P<0.001) reduction in blood glucose level which was accompanied by an increase in body weight. EEAS treatment significantly (P<0.05 to P<0.01) reversed abnormal status of lipid profile towards near normal levels compared to diabetic control mice. In addition, there was a significant (P<0.001) decrease in the activities of SGOT and SGPT in extract-treated diabetic mice compared to untreated diabetic mice indicating the protective role of the extract against liver damage. The findings of this study suggest that ethanol extract of garlic grown in Bangladesh possesses the capability of managing hyperglycemia and complications of diabetes in streptozotocin-induced diabetic mice. Therefore this plant may be considered as a potential resource for the development of alternative medicine in the management of diabetes mellitus.