Vol. 3, Issue 3 (2017)
Evaluation of Antiobesity and Hypolipidaemic effect of Sandroos (Trachylobium hornemannianum Hayne.) in Diet Induced Obesity in Rats
Author(s): Heena Kausar S, Najeeb Jahan, Kamal Ahmad
Abstract: Back ground & objective: Sandroos (Trachylobium hornemannianum Hayne.) has been mentioned in Unani literature as an important drug for the treatment of obesity (Simne mufrit) and its associated disorders. Therefore, the present study was carried out to evaluate its effect in Diet induced obesity in rats. Materials and methods: The study was carried out on 48 Sprague Dawley rats of either sex, divided into six groups of 8 animals in each. Group I received vehicle and normal diet throughout the study; Group II was given Sandroos (350mg/kg) orally, along with normal pellet diet; Group III was given only Cafeteria diet (CD); Group IV was given Sandroos (350mg/kg) along with CD; Group V was given Sandroos (700mg/kg) along with CD and Group VI was given Orlistat (14mg/kg) along with CD throughout the study. During the study, food intake was recorded daily and on every 15th day body weight, locomotor activity, body temperature, and RBS were recorded. On 46th day, animals were sacrificed and Serum lipid profile, organ weight, fat pad weight, lipid content, histopathological examination of adipose tissue and body composition of animals was analyzed. Results: A significant (P<0.01) decrease in food intake, body weight, RBS, lipid content, adipose cell size, fat pad weight, triglyceride(TG), total cholesterol, LDL and VLDL concentration was found in test drug treated groups and highly significant (P<0.001) effect was observed in single dose treated group. The findings of double dose treated group were found near to plain and standard control groups. Significantly (P<0.01) increase in body temperature, locomotor activity and HDL was observed in group II. Conclusion: Sandroos has shown to possess potent hypolipidaemic and antiobesity effect in its therapeutic dose without any observable side effects. Thus, the study validated the claims of Unani physicians.