Vol. 3, Issue 5 (2017)
Estimation of salivary & serum level in oral submucous fibrosis patients
Author(s): Ankur Bhargava, Ahmad Danish Rehan, Sonal Saigal, Uddipan Kumar, Pragya Thakur, Tasnim Kausar
Abstract: Background: Oral submucous fibrosis (OSMF) is also considered as an Asian version of sideropenic dysphagia, wherein chronic iron deficiency leads to mucosal susceptibility to irritants, such as chillies and areca nut products. Iron content can thus be a predictor for the progression of the condition therefore, biochemical assessment of oral precancerous conditions may help in early diagnosis and prognosis. Hence, the present study was aimed to evaluate serum and salivary iron level in OSMF patients. Aim: The aims of this study were to estimate the levels of iron in saliva and serum of patients with OSMF and to correlate change in levels of iron with the histopathological grading of OSMF. Materials and Methods: The study group comprised of 30 clinically diagnosed and histopathologically confirmed cases of OSMF; 10 age- and sex-matched controls were also enrolled in the study. Blood and saliva was collected and they were subjected for analysis by using atomic absorption spectrometry and a differential pulse anodic stripping voltmeter. Results: Both salivary and serum iron levels were decreased in OSMF patients. Conclusions: Iron may have been used for the excessive collagen synthesis occurring during progression of OSMF. Hence salivary and serum monitoring may play a crucial role in the early diagnosis and prognosis of OSMF.
Please use another browser.