Study on serum uric acid levels in patients with chronic kidney disease and associated factors
Dr. C Hariharan MD, Dr. CH Suresh
Introduction: Hyperuricemia, previously thought as a consequence of renal impairement, has been recently identified as an independent risk factor for the development of Chronic Kidney disease. (CKD) This study was done to find out the prevalence of hyperuricemia and the various clinical, demographic and social factors associated with hyperuricemia in patients with CKD. Material and methods: This descriptive study was conducted at Chengalpattu medical college. The study population included 102 patients with CKD and 60 subjects without CKD as controls from the department of General medicine. Detailed history, anthropometry and clinical examination were recorded from all patients and uric acid levels were compared between the two groups. Other study parameters were analysed within the CKD group. Results: Comparison was done between patients with CKD and the control group. Mean uric acid level in CKD group was 8.0 mg/dl and in non CKD group was 5.03 mg/dl which was found to be statistically significant (p value<0.001). Among the CKD group Uric acid level is significantly higher in obese subjects (with raised waist hip ratio, high body mass index (BMI)). Uric acid level is significantly higher in diabetic and hypertensive CKD patients. Prevalence of coronary artery disease is significantly higher in CKD subjects with higher uric acid level. Conclusions: Prevalence of hyperuricemia is significantly higher in CKD patients compared to normal subjects. Significantly high uric acid levels were recorded in subjects with raised waist hip ratio, higher BMI, those with diabetes and hypertension.