International Journal of Medical and Health Research

International Journal of Medical and Health Research


(MCI Approved Journal)

ISSN: 2454-9142

Vol. 4, Issue 11 (2018)

Use of non-invasive methods for the assessment of advancement of liver fibrosis in patients with chronic liver disease

Author(s): Dr. Shishirendu Parihar, Dr. Shubham Dubey, Dr. TN Dubey, Dr. Chandrakant Bhaskar
Abstract:
Background: Chronic liver diseases (CLD) cause significant morbidity and mortality worldwide. Liver biopsy is the gold standard for assessment of liver fibrosis. There is a need to non-invasive methods for assessment of advancement in liver fibrosis.
Aims and Objectives: To compare the findings of fibroscan score with FIB-4 scores, APRI scores and AST/ALT Ratio.
Materials and Methods: Seventy six patients of CLD confirmed using abdominal ultrasound examination, biochemical and radiological parameters were studies at Dept. of Medicine, Gandhi Medical College/ Hamidia Hospital Bhopal from 2016 to 2018. Detailed demography including age and sex was obtained from each patient. Fibroscan examinations, serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST) and serum creatinine were measured. Estimation of AST/ALT ratio, APRI score and FIB-4 was also estimated for the study cohort.
Results: Male preponderance (84.2%) was observed with mean age of 44.51± 14.89 years. Mean Stiffness score was 42.70±20.86. Mean AST/ALT Ratio, APRI and FIB-4 Score was 1.84±2.62, 2.24±2.77 and 5.20±4.05 respectively. Majority of the patients had stage F4 of liver fibrosis (82.89%). Stiffness score, APRI and FIB-4 score was significantly higher in patients who were having liver fibrosis stage of >F2 as compared to patients who had stage of ≤F2 (p<0.05). Pearson correlation revealed that FIB-4 score (r=0.422, p=0.022), AST/ALT Ratio (r=0.352, p=0.012) and APRI (r=0.519, p=0.026) were positively correlated with the stiffness score.
Conclusion: The prevalence of advanced liver fibrosis is high. There is need of early diagnosis. Fibroscan along with serum markers including FIB-4 scores, APRI scores has been shown to be helpful for the diagnosis of advancement of fibrosis.
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