Aim: The aim of the present study is to compare between sublingual administration of misoprostol and vaginal administration in the management of missed abortion.
Materials and Methods: This was a prospective study conducted in the Department of Obstetrics and Gynecology in SMGS hospital. A total of sixty women diagnosed as missed miscarriage in first trimester on UGS in the out-patient clinic. Participants were randomly divided to receive 400 μg of misoprostol either sublingually or intra vaginally every three hours for a maximum of 4 doses.
Result: During the follow-up of our cases we found that sublingual route is more effective than vaginal route in the management of missed abortion. The difference between the two groups in percentage of conceptus expulsion was statistically significant, 80 % in the sublingual group and 62 % in the vaginal group. Compared with vaginal group, those women in sublingual group experienced more complications including altered taste (62% vessus4%) vomiting (20 versus 10%), and diarrhea (10% versus 4%).IAI between two group was also significant, 14.25±1.5 in vaginal group versus 10.2± 1.6 in sublingual group.
Conclusion: From our study, we conclude that sublingual misoprostol is an effective and safe medical method for completion of abortion in missed abortion in first trimester, although side effects are more common in sublingual group.