Vol. 4, Issue 11 (2018)
Study of a regimen of medical abortion for second trimester termination of pregnancy using mifepristone and misoprostol
Author(s): Dr. Snehil, Dr. Abha Sinha, Dr. Sapna
Abstract: Termination of pregnancy between 13-26 weeks constitutes about 10-15 % of all pregnancy terminations but is responsible for two third of all major complications and 50%of all abortion related maternal deaths This study assesses the efficacy of a newer regimen using oral mifepristone 200 mg followed by misoprostol 800 mcg per vaginum 12 hours and 24 hours later in two groups for second trimester pregnancy termination aiming to increase the acceptability and reduce the hospital stay. A total of 100 pregnant women willing for second trimester termination of pregnancy were assigned two groups according to time interval between administration of mifepristone and misoprostol. In group 1, misoprostol 800 mcg was administered per vaginum 12 hours after oral 200 mg mifepristone and in group 2, misoprostol 800 mcg was given after 24 hours of oral 200 mg mifepristone. Successful abortion occurred in 97% women in group1 and 98.8% women in group 2.The acceptability was found to be better in group 1. The proposed newer regimen has comparable efficacy and acceptability as the older regimen and requires lesser hospital stay which is a major concern for the females. At the same time it reduces hospital burden which stands more important for the developing country like India, where health care facilities are already scarce.
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