Vol. 4, Issue 12 (2018)
A prospective study for the association between kidney disease and pre-diabetes
Author(s): Dr. Shilpi Sikarwar, Dr. Ajay Pal Singh
Abstract: Background: Globally, diabetes is the leading cause of kidney disease and kidney failure. Prediabetes is approximately twice as common as diabetes, affecting 20-35% of adults. The fasting glucose and glycated haemoglobin (HbA1c) levels consistent with prediabetes are independent risk factors for hyper filtration in the kidneys and the presence of albumin in the urine -both indicators of kidney damage. Aims and Objectives: To study the association between pre-diabetes and kidney diseases. Materials and Methods: This is a prospective study which was conducted on 150 subjects with 50 normoglycemic controls and 100 pre-diabetes patients having fasting plasma glucose (FPG) more than 100 mg/dl and less than 126 mg/dl or Postprandial Blood Sugar (PPBS) more than 140mg/dl or less than 199mg/dl and /or HbA1c 5.6 to 6.4%. Physio-chemical parameters were recorded and assessed to understand the correlation between pre-diabetic conditions and kidney disease. Results: Kidney disease prevalence is high among people with prediabetes. Majority of the cases had fasting blood between 100-109 mg/dl, all controls had FBS range less than 100 mg/dl. Mean FBS in cases was 111.28±7.06 mg/dl and mean FBS in controls was (77.62±10.2 mg/dl. Post prandial blood sugar in pre diabetic cases ranged from 160- 179, all controls had PPBS< 140 mg/dl, mean PPBS in cases was 171.4±13.63 mg/dl and mean PPBS in controls was 116.52±12.86 mg/dl. Hb1c in pre-diabetic cases ranged from 5.7 – 6.0%, all controls had HbA1c <5.7%, mean HbA1c in cases was 6.03±0.19 and mean HbA1c in controls was 4.5±0.61%. 18% cases and none of the controls showed evidence of kidney disease. This difference of evidence of kidney disease between cases and controls was statistically significant. Conclusion: Kidney disease prevalence was high among the prediabetes patients. Thus prediabetes can be target for early intervention for prevention of chronic kidney diseases by lifestyle changes.
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