Vol. 4, Issue 12 (2018)
A comparative study on measure the efficacy of midazolam in reducing the dose of propofol in co induction: A double blind ranadomized trial
Author(s): Dr. Zameeruddin, Dr. Syed Ahamed Peerzade
Abstract: Priming principle refers to administration of a subanaestheic dose of an agent prior to its actual anaesthetic dose. Propofol is an effective substitute to midazolam for intravenous induction. The aim of the present study was to evaluate the efficacy of priming technique in relation to induction agents. Clinical efficacy in terms of dose reduction and alteration in peri-intubation haemodynamics was compared in midazolam induction and midazolam Propofol co-induction groups along with a control group. The study was carried out in 30 patients scheduled for general surgery, who were randomly divided into two equal groups. Group I received. Midazolam 0.05 mg/kg BW (20% of the pre-calculated induction dose), group II received 0.05 mg/kg normal saline. This was followed by induction with Propofol 2 minutes later in all the two groups at a predetermined rate till the bispectral index value of 45 was attained. The demographic data were comparable for age, weight and sex in both the groups. Total patients were divided into two groups with 30 patients each. It was observed that total induction dose of Propofol was significantly decreased in the study group 95 mg compared to control group 155.6 mg. Heart rate was better maintained in study group with minimal post-intubation response. The values of systolic, diastolic and mean blood pressure observed at 1 min after induction also showed significant decrease in control group compared to study group. Conclusions: Propofol produces smooth, rapid, pleasant and safe induction. Priming with Propofol can be practiced due to its cost effectiveness and better haemodynamic profile and safety. The results showed a significant decrease in induction dose requirement in both the groups but haemodynamic stability during induction and intubation was more in Propofol auto-co-induction group.
Please use another browser.