Vol. 4, Issue 2 (2018)
A study of propofol auto-co-induction versus midazolam-propofol co-induction using priming principle by bispectral index analysis for ambulatory surgery
Author(s): Dr. Krupali, Dr. Bhavna Soni, Dr. Pragna Vachhrajani
Abstract: Aims and objective: This study was performed to evaluate whether “priming principle” applied for induction dose of propofol which will affect the total dose requirement and thereby favorably influences peri intubation hemodynamics. And also to compare the recovery criteria in propofol auto-co-induction and midazolam–propofol co-induction in ambulatory surgery. Method: The study was carried out on 90 patients of ASA I and II physical status, aged 18-55 years, undergoing ambulatory surgeries under general anaesthesia, who were randomly divided into three groups of 30 patients each: Group PP (Propofol- Propofol) received 0.5 mg/kg propofol IV, group MP (Midazolam-Propofol) received 0.05 mg/kg midazolam IV and group C (Control) received 3 ml of normal saline 3 minutes before induction. All patients were induced with Inj propofol 2 mg/kg until BIS value reaches to 45-50 (Speed of Injection is 30 mg/ 10 sec). Results: The total requirement of propofol to maintain BIS between 45-50 during induction was decreased in both the study group compared to control group (P<0.05) but more reduction (26%) was seen in midazolam co-induction group (P<0.001) compared to auto co-induction group (17%) (P<0.05). While hemodynamic stability and early discharge was observed in propofol auto-co-induction group. Conclusion: In day care anaesthesia, propofol auto-co-induction appears to be a safe alternative technique to midazolam-propofol co-induction looking to overall reduction in propofol requirement and discharge time from hospital.