Vol. 4, Issue 3 (2018)
Unjustified abnormalities of analytes in the second trimester
Author(s): Maryam Nakhaee Moghadam, Marzie Davoodi, Raziyeh Behzadmehr
Abstract: There is a justified relationship between high levels of each of the hCG or dimeric inhibin alpha in the second trimester and the undesirable complications of pregnancy. The findings reported are similar to the findings that have to do with high levels of AFP, and they include: intrauterine growth restriction (IUGR), Pre-eclampsia, Preterm birth, fetal death, and stillbirth. In addition, when some indicators are at a high level, the likelihood of undesirable result will increase. Combined screening increases aneuploidy diagnosis. For this very reason, for women seeking pregnancy cares in the first trimester. The major abnormalities and minor ultrasound markers are remarkably helpful in aneuploidy diagnosis. Except for a few cases, the risk of aneuploidy coincidence with the major abnormalities is so widespread that calls for conducting aggressive tests to determine fetal karyotype or chromosomal microarray. When a fetus is suffering from an abnormality, it is likely to suffer from other abnormalities as well. In spite of their significant effect on prognosis, the likelihood of their diagnosis by ultrasound is low or impossible. Most of the fetuses suffering from aneuploidies in which the intrauterine fetal death is high (such as 18 and 13 trisomy and tetraploidy) have abnormalities that are visible in the second trimester by applying ultrasound.