Introduction: Although the majority of abortions are performed in first trimester, there is still a need for second trimester MTP due to delayed diagnosis of fetal anomalies, financial difficulties in obtaining abortion services and failure to recognize undesired pregnancy in first trimester. Research suggests that with mifepristone pretreatment lower doses of misoprostol may be sufficient to achieve comparable efficacy. However there is little information on optimal medical regimen using mifepristone and misoprostol for second trimester MTP.
Objectives: To compare Induction Abortion Interval (IAI), to evaluate completeness of abortion and to assess the safety of drugs.
Methodology: This study was prospective comparative Randomized Controlled Trial without blinding where 56 eligible women were randomly divided in to two groups. In study group tablet Mifepristone 200 mg was given orally to the selected women. After 24 hrs, tablet Misoprosotol 400mcg was kept pervaginally every 3 hourly to a maximum of 5 doses. In control group, only tablet Misoprostol 400mcg was kept pervaginally every 3 hourly to a maximum of 5 doses.
Results: In Misoprostol alone group mean IAI was 11.18 hrs while in combined group it was 8.51 hrs. In Misoprostol alone group 78.6% cases had complete abortion while in combined group it was 96.4%. Side effects were more common in misoprostol alone group.
Conclusion: Using combination of mifepristone and misoprostol is a safe, non invasive method with a high success rate, short IAI, less side effects