Background: Preeclampsia is one of the most important gestational disorders that lead to both maternal and fetal bad outcomes. It is a hypertensive disorder of pregnancy characterized by endothelial dysfunction.
Objective: The objective of this study is to determine the lipid profile pattern among patients with pre-eclampsia. The present study was planned to determined the Lipoprotein (a), serum total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein cholesterol in pre-eclamptic and normal pregnant women. Method: In this present study, serum samples were collected from 30 pregnant females diagnosed as pre eclampsia and 20 normal pregnant females. Serum levels of lipoprotein (a) [Lp (a)], total cholesterol (TC), triglyceride(TG), high density lipoprotein (HDL) and low density lipoprotein(LDL) and very low density lipoprotein (VLDL) in pre-eclamptic and normal pregnant women were determined.
Results: A significant difference in Lp (a) and lipid profile parameters was observed in preeclamptic patients. Lipoprotein (a) triglyceride and VLDL were significantly increased while HDL was significantly decreased in preeclamptic group compared to normal pregnant women. Positive correlation was found between serum Lp (a) and blood pressure in preeclampsia patients.
Conclusion: The study suggested that lipoprotein (a) [Lp (a)], total cholesterol (TC), triglyceride (TG), high density lipoprotein(HDL) and low density lipoprotein (LDL),and very low density lipoprotein (VLDL) should be considered as important determent risk factors in pre-eclampsia and the obtained data may help in developing strategies for prevention and early diagnosis of the disorder.