Vol. 4, Issue 3 (2018)
Estimation of serum prolactin in children admitted with seizure disorders
Author(s): Dr. Rita Chaudhary, Dr. Amit Kumar, Dr. Ram Binay Sinha
Abstract: Most cases of seizure occur as the result of central nervous system infection, brain injury, stroke, brain tumors, and birth defects, through a process known as epileptogenesis. The etiology in many cases of seizure disorder remains largely unknown. Sometimes it may be very difficult to differentiate between true seizures and seizure like illnesses (Pseudoseizure), even by experienced clinicians. EEG is many times not readily available and also not highly specific or sensitive. Several investigators have now reported elevated plasma Prolactin levels in patients with epileptic seizures (1-3). The aim of this study was to establish the fact that plasma Prolactin level estimation may be of great importance in the differentiation of true epileptic seizures from Pseudoseizure. The study was planned in the department of Biochemistry, Patna medical College, Patna. 120 patients diagnosed with seizure were enrolled in the study. The cases were divided into four groups, each having 30 members. Blood samples were collected after 2 hours of the seizure episode or at the time of presentation, whichever was later. Then serum prolactin estimation was done by chemiluminescence method. Prolactin levels were found to be significantly higher in all seizure subtypes in comparison to pseudoseizure. Our observations in this study suggested that plasma Prolactin level may be measured in children with seizure especially when there is difficulty in separating the cases of true seizure from pseudoseizure clinically. This may be very useful in children with functional neurological disorders also. Larger studied are further required.