Background: Alcohol use among HIV-positive individuals is associated with decreased adherence to antiretroviral therapy (ART) and consequently poorer HIV treatment outcomes.
Aims and Objective: To study and compare the clinical and biochemical spectrum of people living with HIV/AIDS (PLHA) on Anti-Retroviral therapy with special reference to alcohol.
Materials and Methods: Hundred patients who were on Anti-Retroviral therapy were studied in the Department of Medicine G.R. Medical College, Gwalior from February 2016 to September 2017. Patients were divided as cases (n=50; with alcohol abuse) and control (n=50; without alcohol abuse). Hemoglobin, total leukocyte count (TLC), peripheral smear examination, random blood sugar, liver function tests, serum bilirubin, serum protein and serum albumin were estimated.
Results: Mean age between both the groups were comparable (35.42±9.38 vs 39.30±9.39; p=0.089). Body weight was significantly increased from 49.27±7.33kg to 53.75±6.85 kg before and after ART therapy respectively among cases and 44.04±6.18 kg to 52.56±8.12 kg before and after ART therapy among control group (p<0.001). CD4 count was significantly increased from 238.96±110.81 before ART to 353.24±127.15 after ART in Cases and 227.22±111.98 before ART to 493.08±117.42 after ART in control (p<0.001). Due to alcohol, among cases less weight gain (4.48 kg in Cases vs. 8.52 kg in control) and less increase in CD4 count (114.28 in cases vs. 265.86 on control) was observed as compared to control group who do not consumed alcohol.
Conclusion: HIV positive subject with alcohol use along with ART therapy can have detrimental effects of clinical as well as biochemical parameters which can further deteriorate the disease condition.