International Journal of Medical and Health Research

ISSN: 2454-9142

Vol. 4, Issue 4 (2018)

A comparison of epidural butorphanol 2mg and fentanyl 75 mcg for postoperative analgesia using combined spinal epidural anaesthesia technique: A randomized double blind clinical study

Author(s): Dr. Siddharth Sharma, Dr. Shraddha Naik, Dr. PB Jamale, Dr. VK Dhulkhed, Dr. Anand Prasoon
Objectives: The aim of this study was to assess the effect of Butorphanol & Fentanyl used as epidural analgesic agent in patients undergoing elective Abdomino-Pelvic and lower limb surgeries. Primary Objective is to compare duration of analgesia (hours) and quality of analgesia. Secondary objective is to compare hemodynamic changes and any adverse reaction.
Materials and Methods: Forty patients of either sex, scheduled for elective Abdomino-Pelvic surgeries and Lower Limb surgeries under CSEA technique were included in the study. In postoperative period, patients received either epidural butorphanol 2mg in 10ml NS or fentanyl 75mcg in 10ml NS. Duration of analgesia, which is the time interval between start of analgesia till patient complaints of pain (VAS >4) was noted in both groups. Quality of analgesia was assessed using pain score in both the groups. Heart rate, blood pressure and respiratory rate were monitored at regular intervals and were compared between the 2 groups. Side effects like sedation, pruritus, nausea, vomiting, hypotension and respiratory depression were noted.
Results: Demographic profile was comparable in both groups. Duration of analgesia was longer in butorphanol group (357.30 ± 53.52 minutes) in comparison to fentanyl group (207.50 ± 30.24 minutes), which was clinically and statistically significant. Quality of analgesia was better in butorphanol group. Sedation was the main side effect in butorphanol group. Incidence of pruritus, vomiting, hypotension and respiratory depression was more in fentanyl group.
Conclusion: Epidural butorphanol provides longer duration of analgesia, better quality of analgesia with less number of epidural doses and fewer side effects like sedation, which are statistically significant when compared to epidural fentanyl.
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