Vol. 4, Issue 4 (2018)
Clinical evaluation of hematological profile of children’s affected by sickle cell disease
Author(s): Dr. K Vanaja
Abstract: Iron deficiency in sickle cell patients may result in lowering the intracellular haemoglobin concentration and this may ameliorate sickling. The patients with sickle cell disease do not acquire excessive iron burden during the first two decades of life. Hence the study was planned with the foremost purpose to assess the haematological profile of children in special reference to body iron status of patients with sickle cell disease. All the established cases of children detected with sickle cell disease or sickle β thalassemia were imperilled to comprehensive haematological examination in distinct allusion to body iron store by assessment of serum iron, TIBC, % transferrin saturation and serum ferritin to find out total body iron store. Thus, based on present and previous studies available, out of various parameters for diagnosis of iron status in SCD-SS patients, low MCV and MCH are more consistently associated with iron deficient state. Such patients need to be further evaluated on long term basis after giving trial of iron therapy.
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