A study of serum uric acid levels in essential hypertension
Dr. Sushil Kumar, Dr. Mala Mahto, Dr. Ayan Banerjee, Dr. Ravi Kiriti, Dr. Alok Ranjan, Dr. Archana Bharti
Serum Uric acid (SUA) is an independent risk factor for cardiovascular and renal disease has been established by numerous epidemiological and experimental studies, particularly in patients with hypertension, heart failure or coronary heart disease, cerebral-vascular events in individuals with diabetes mellitus, and cardiac ischemia in hypertension. The mechanism(s) by which Uric Acid may engender organ damage is still incompletely understood, but there is increasing evidence that endothelial dysfunction is a fundamental mechanism whereby this substance may affect cardiovascular and renal function and structure. Hyperuricemia is a strong predictor of hypertension and BP progression. The aim of present study was to know the possibility of hyperuricemia causing hypertension, to see a relationship between the serum uric acid levels and severity and duration of hypertension. This study had been conducted in the Department of Biochemistry AIIMS Patna on adult patients who were referred from Out-Patient Departments (OPD). Relevant demographic, personal, medical and surgical details of the patients are recorded in the department during their enrolment for biochemical investigations. Fifty (50) patients with the essential hypertension were retrieved from records they were considered as case study group. The fifty (50) normotensive age sex matched subjects were retrieved from records and they comprised as the control study group. The blood samples were analysed on fully automated clinical chemistry analyzer, Beckman Coulter AU 480. Serum uric acid (SUA) was estimated by Uricase method. Thus based on the study carried out we can conclude that Serum uric acid waselevated in hypertensive as compared to normotensive individuals. Serum uric acid can be used probably as an early biochemical marker to determine the severity of hypertension as stage 2 hypertensive had more elevation in serum uric acid levels as compared to other hypertensive.