Vol. 4, Issue 7 (2018)
Original research article: Study of serum levels of vitamin D3 in females of hypothyroidism
Author(s): Dr. Chitra Upadhyay, Dr. Sangeeta Meena, Dr. BP Meena, Dr. Bhavani Kocher
Abstract: Background: Thyroid is an endocrine gland which is present in the neck below the Adam’s apple and secretes thyroid hormones i.e. T3, T4, TSH and calcitonin. Vitamin D is fat soluble and also known as sunshine vitamin. It is of 2 types D3 and D2. Vitamin D3 (cholecalciferol) is found in animal products and Vitamin D2 (ergocalciferol) is found in plants. Both are converted into active form of Vitamin D by a series of pathway in the body and the active form i.e. calcitriol is circulated in the blood and combines with the Vitamin D receptor (VDR). The VDR function with the help of calcitonin which is a hormone secreted by thyroid gland. The receptors of thyroid and vitamin D are steroid hormone receptors. Objectives: The Objectives of the study is to determine the level of Vitamin D3 in female patients of hypothyroidism. Methodology: In the hypothyroid patients, the level of T3 and T4 is low and level of TSH is high. The level of vitamin D and Serum calcium decreases in hypothyroidism. The detection of T3, T4, TSH and Vitamin D is done by an automated machine known as siemens Advia centaur XP which works on the principle of chemiluminescence. The serum calcium is analyzed by Beckman coulter which works on the principle of calorimeter. 2 groups were formed, 50 subjects in study group which were hypothyroid and vitamin D deficient and 50 subjects in control group which were normal. Results: On the basis of 3 age ranges i.e. 1-20, 20-40 and above 40 were showing hypothyroidism in vitamin D deficiency. Another criteria on the basis of diet was studied which shows that non-vegetarians have low absorption of vitamin D with hypothyroidism because the meat contains fat which causes hindrance in the absorption. Conclusion: From our study I would like to conclude that the levels of FT3 and FT4 were low and TSH was high, serum Calcium was low and vitamin D was low as compared to the normal healthy subjects. There is significantly high level of TSH in case group as compared to control group. The above study also concludes that vitamin d supplements should be given to hypothyroid patients and vegetarians are healthier than non-vegetarians.
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