Vol. 4, Issue 7 (2018)
Prognostic validity of mean platelet volume in children with nephrotic syndrome
Author(s): Gamal B Mohamed, Asmaa N Moustafa, Hanan M Kamel, Mohammed G Hassan
Abstract: Background: Nephrotic syndrome (NS) is a common childhood chronic kidney disease. Early prediction for the prognosis of the nephritic syndrome have not been determinate yet. Objective: To evaluate mean platelet volume as a prognostic biomarker in patients with nephrotic syndrome. Subjects and Methods: This was prospective comparative study. Eighty children were included in this study which was conducted in the period from August 2014 - 28th February 2015 in the pediatric department of El Minia university hospital, Minia, Egypt. Venous blood samples were obtained during active and remission phases of nephrotic syndrome for complete blood count and mean platelet volume assessment. Results: Mean platelet volume values decreased in patient groups in both active and remission phases than the control group (p-value< 0.001). There is an inverse correlation between platelets count and mean platelet volume (MPV) in group 1 during active phase and remission phase. Conclusion: MPV can be used as a prognostic marker in patients with NS so it may be used to assess the clinical course and response to treatment.
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