Vol. 4, Issue 8 (2018)
Variations in serum uric acid and serum magnesium levels in pre-eclamptic women
Author(s): Dr. S Laxmi Narayana, Dr. Rentapalli Babu Rao, Dr. Sreevani Namani, Dr. Md. Suleman
Abstract: The purpose of the present study was to estimate serum uric acid and magnesium levels in pre-eclamptic, eclamptic and normotensive groups to identify women who are at high risk of developing the disease early in pregnancy. The study may provide possible biochemical parameter in toxemias of pregnancy. This is because early identification of biochemical markers of the disease would not only facilitate to identify those at increased risk for pre-eclampsia but also help in determining those patients likely to benefit from interventional measures. This study was conducted in the Department of Biochemistry, Gandhi Medical College, Secunderabad, Telangana, India. The cases for the study were selected from the antenatal outpatient, Gandhi Hospital, Secunderabad, according to specific criteria like women with age group between 18-29 years, primigravide with known last menstrual period and gestational age between 20-30 weeks. A total of n = 38 subjects were selected and categorized into three groups. 24 (n ꞊ 24) among n ꞊ 38 women, were Pregnancy Induced Hypertensive (B.P. >140/90 mmHg), included in experimental group and remaining 14 were normotensive (B.P. <140/90 mmHg) considered as controls (n ꞊ 14). The experimental group was further categorized into two groups, with n = 18 subjects in pre-eclampsia, and n = 6 in eclampsia. The data obtained was subjected to one-way analysis of variance statistical analysis. The serum uric acid levels studied in various study groups showed significant increase in pre-eclamptic (n ꞊ 18) and eclamptic (n ꞊ 6) the difference being statistically significant at p≤0.001. The mean serum uric acid level values for women with pre-eclampsia (4.02 ± 0.17 mg/dl, n ꞊ 18) and eclampsia (4.98 ± 0.57 mg/dl, n ꞊ 6) were significantly higher than those of controls (3.88 ± 0.18 mg/dl, n ꞊ 14) which is statistically significant at p < 0.001. Moreover, it was also experimentally found that the individual values of serum uric acid in pre-eclamptics and eclamptics were relatively higher than those of the average values of normotensives. Although mean serum uric acid values are elevated in women with pre-eclampsia, the clinical utility of serum uric acid values in differentiating various hypertensive diseases of pregnancy appears to be limited. In the setting of chronic hypertension, however, a serum uric acid level of > or = 5.5 mg/dl could identify women with an increased likelihood of having superimposed pre-eclampsia. The mean serum magnesium level in pre-eclampsia (Group II) and eclampsia (Group II) was 1.84 ± 0.09 and 1.77 ± 0.03mg/dl respectively. The serum magnesium levels were observed to be decreased in pregnancy. Serum magnesium levels were observed to be significantly decreased in the experimental group III (eclampsia). Whereas, in pre-eclampsia though there was a marked decrease in serum magnesium level, the decreases were not statistically significant. The prevalence of magnesium deficiency was higher in pregnant women.