Vol. 4, Issue 8 (2018)
Assessment of magnesium sulphate on decreasing hemodynamic stress responses during laparoscopic abdominal surgeries
Author(s): Dr. Shashi Bhushan Sinha
Abstract: Anaesthesia and surgery induced stress response can be modulated by premedication drugs. Magnesium blocks release of catecholamine from both adrenergic nerve terminals and adrenal gland. Intravenous magnesium sulphate inhibits catecholamine release associated with intubation. Magnesium also produces vasodilatation by acting directly on blood vessels, and in high doses, attenuates vasopressin mediated vasoconstriction. The objective of this study is to compare the influence of magnesium sulphate premedication on stress attenuation during laparoscopic abdominal surgery. The study is conducted in HIMS in Department of Anaesthesia. Total 50 patients having are group of 40-58 year were enrolled in to the study. As per the classification of the American Society of Anesthesiologists I and II physical conditions posted for lower abdominal surgeries were enrolled on to the study. The enrolled 50 patients were divided in 2 groups. The Group-A patients includes the 25 patients & Group- B patients includes the 25 patients. The patients in group A received magnesium sulphate while those in group B received normal saline. In the group a administered with the magnesium sulphate had same pulse rate as compared to normal saline administered patients. The Systolic Blood Pressure, Diastolic Blood Pressure and Mean Arterial Pressure was found to lower in group A administered with the magnesium sulphate. The magnesium sulphate attenuated hemodynamic and Neuro endocrine stress response of General anaesthesia. The magnesium sulphate administered group showed better intra operative stability and blood glucose control on comparison to saline administered group. During laparoscopic abdominal surgeries magnesium sulphate have effectively modulated Neuro endocrine stress response of general anaesthesia as analysed by blood pressure parameters.
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