Vol. 5, Issue 1 (2019)
Cytotoxic and apoptotic effects of Pancha Paasana Chendhuram, a herbo-mineral Siddha medicine, against human cervical cancer cells (HeLa cells)
Author(s): Venkataraman Manjari, Rajagopal Pattarayan
Abstract: Siddha system of medicine finds important place in the management chronic ailments including cancer. In vitro studies using a variety of cancer cell types have shed light on the mechanistic insights into the anticancer effect of various regimens including Siddha medicines. Pancha Paasana Chendhuram (PPC) is a herbo-mineral formula claimed to possess significant anticancer activity in Siddha system. In the present study, PPC was investigated for its apoptosis mechanism using human cervical cancer cells. PPC up-regulated Bax and p53 and down-regulated BCl2 mRNAs expression in human cervical cancer cells (HeLa cells).
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