Vol. 5, Issue 1 (2019)
Relationship of gallstones with cholecystitis and carcinoma of gallbladder: A histopathological evaluation
Author(s): Dr. Ravi Bhushan Raman, Dr. Amit Kumar Sinha, Dr. Bipin Kumar, Dr. Gyan Bhushan Raman, Dr. Neelima Kumari
Abstract: In recent years, potential precursors of gallbladder carcinoma have been identified, making their recognition by diagnosticians clinically relevant. Gallbladders are common surgical specimens and most procedures are performed for cholecystitis and cholelithiasis. Hence based upon these literature findings the present study was planned to evaluate the relationship of gallstones with cholecystitis and carcinoma of gallbladder based upon histopathological examination. The present study was planned in Indira Gandhi Institute of Medical Sciences, Patna in Department of Pathology in 50 patients undergoing cholecystitis. All non-neoplastic and neoplastic epithelial lesions of the gallbladder were included in the study; whereas patients with Mesenchymal and Lymphoid neoplasms were excluded from the present study. The gallbladder specimens of all 50 patients undergone cholecystectomy, were processed for histopathological examination. Out of 50 patients, 39 patients diagnosed as various types of cholecystitis were associated with gallstones. Only one case of gallbladder carcinoma was detected in our study, which was not associated with any gallstone. From the above findings it can be concluded that Gallstones are often clinically silent and become symptomatic when they incite inflammation. Association of carcinoma of gallbladder and cholelithiasis is frequently reported. However, in this study there were no associated gallstones in the gallbladder cancer.
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