Vol. 5, Issue 1 (2019)
Assessment of renal function after administration different doses of aspirin
Author(s): Dr. Gyan Bhushan Raman, Dr. Umesh Rajak, Dr. Ravi Bhushan Raman, Dr. Dilip Kumar, Dr. Sweta Kumari
Abstract: Aspirin is commonly used by elderly patients. In previous studies we found transient changes in renal function induced by low doses of aspirin. Hence from the above literature findings the present study was planned to assess the effect of low dose aspirin altering renal function or not. As low dose aspirin has been reported to be a risk factor of hyperuricemia. The present study was planned in the VMMC & Safdarjung Hospital, New Delhi in total 40 patients without any complications. The patients were those enrolled in long-term care, as well as new patients with various medical conditions necessitating the use of low dose aspirin that were in stable clinical conditions throughout the study. The patients were divided in two study groups based on the dose of the administered aspirin. The group: A patients received the 100 mg/day Aspirin for 4 weeks and Group: B patients were received the 300 mg/day Aspirin for 4 weeks. In conclusion, the results of the present study indicate that low dose aspirin administration in elderly inpatients for a short time has a significant effect on their renal tubular function. The dose dependent study concluded that the dosage of 300 mg/day aspirin was found to induce a considerably higher changes in renal function and secretion of uric than 100 mg/day. The dosage of 100 mg/day aspirin can be used with more safety during the treatment.
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