Vol. 5, Issue 1 (2019)
Comparative evaluation of immunological response of Hepatitis B vaccines administered in pediatric patients
Author(s): Dr. Rizwan Haider, Dr. Shobhakant Choudhry
Abstract: Hepatitis is inflammation of the liver tissue. Some people may have no symptoms whereas others develop yellow discoloration of the skin and whites of the eyes, poor appetite, vomiting, tiredness, abdominal pain, or diarrhoea. The current retrospective study was planned in the Department of Paediatrics in Darbhanga Medical College and Hospital, Laheriasarai from Jan 2016 to Dec 2016. Total 80 Childs of age 1 to 12 months were enrolled in the present study. Cases having HBsAg positive mother, who had already received a hepatitis B vaccine, immunoglobulin or a blood product, and cases having an acute illness contraindicating routine immunization were excluded from the present study. The main objective of this study is to evaluate the hepatitis B antibody response to a combination vaccine containing recombinant DNA hepatitis B vaccine along with DTwP or DTaP vaccine and a recombinant vaccine containing only S antigen and compare the two vaccines. The present study demonstrates the immunological response to the two Hepatitis B vaccines with their antibody responses. Hence from the above findings it can be concluded that 0, 1, 6 schedule produces a higher antibody level than 0, 1, 2 schedule though both the schedules have good seroconversion and seroprotection rates with both the vaccines.