Vol. 5, Issue 10 (2019)
Prognostic value of Interleukins (IL)-6 and Tumor Necrosis Factor (TNF)-α as predictors of systemic complications in Acute Pancreatitis: A Clinico-observational study
Author(s): Dr. Nitika Khanna, Dr. Rati Mathur, Dr. Shyam Sunder Sharma
Abstract: Background: Early assessment of severity in acute pancreatitis (AP) is a key measure to provide rational and effective management. Aim: of this study is to determine the prognostic value of interleukins (IL)-6 and tumor necrosis factor (TNF)-α as predictors of systemic complications in AP. Materials and Methods: total 210 patients with confirmed AP were enrolled in the study. The severity of AP was defined according to Atlanta criteria. Measurements of interleukins and TNF-α were performed on the 1st day and on 3rd day of admission. Results: on day 1st & day 3rd serum levels of IL-6 found highly significantly different (p < 0.000) between the severe group and the mild group and TNF-α was found higher (p < 0.05) in the severe group than in mild cases on day 1st only. On day 1, IL-6 had a higher sensitivity (92%), specificity (86.7%) and accuracy (88%) compared with TNF-α showed low level of sensitivity and diagnostic accuracy on both the days. Conclusion: our study confirmed that by determining the serum concentration of IL-6 on the 1st day and on the 3nd day of admission represents a valuable diagnostic tool in the assessment of severity and course of disease in patients with acute pancreatitis.