Vol. 5, Issue 11 (2019)
Study of electrolyte disturbances and renal parameters in asphyxiated newborn
Author(s): Dr. K N Mishra, Dr. Anil Kumar
Abstract: The fluid and electrolyte shift can occur after birth asphyxia. Calcium is an important second messenger in our body and act as a cofactor for muscle function and several enzyme activities. Hypocalcemia triggers seizure activity and deleterious cardio-vascular sequences in asphyxiated newborns. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a common problem in these neonates accounting for hyponatremia, hyperkalemia results from ischemic insult with eventual renal insufficiency. It is difficult to differentiate the seizure activity due to hypocalcemia and asphyxia. The present study was done in SNCU of Department of Paediatrics, Darbhanga Medical College and Hospital, Laheriasarai, Darbhanga, Bihar. Total 30 cases were taken in the present study. The cases were divided as Group I: 15 cases of Asphyxiated Newborn and Group II: 15 control cases of newborn. The electrolytes (sodium, potassium and calcium) were measured from venous samples taken under aseptic precaution. The serum sodium and potassium levels were measured by ‘electrolyte analyser’ model ROCHE 8190. Serum sodium estimation was done by ion selective electrode method. The Serum calcium levels were measured by ‘end point calorimetric method’ using O cresolphethelin-complexone or OCPC. The data generated from present study concludes that asphyxiated babies also develop hyperkalemia and hypokalemia but to reach to definite conclusion further studies are required. If inappropriate fluid and electrolytes are given, serious morbidity can result from fluid and electrolyte imbalance. So measurement of serum electrolyte is the best way to measure the baby's electrolyte status and the adequacy or excess of electrolyte intake. Hence early identification and time-based intervention of electrolyte abnormality in the early post asphyxiated period will significantly reduce the morbidity and mortality.