Vol. 5, Issue 11 (2019)
Clinical evaluation of level of C-reactive protein in stable chronic obstructive pulmonary disease (COPD) patients from Bihar region
Author(s): Dr. Madan Prakash, Dr. Sunil Kumar
Abstract: Chronic Obstructive Pulmonary Disease (COPD) being a multisystem disorder is frequently associated with significant extra-pulmonary manifestations. The mechanisms underlying the systemic manifestations of COPD should attract great interest, because these account for a large part of morbidity and its assessment and management is critically important for the improvement in future treatment and outcome of COPD patients. These systemic manifestations have been associated with systemic changes including evidence of increased oxidative stress, activation of circulating inflammatory cells and increased levels of pro-inflammatory cytokines. Hence based on the above findings the present study was planned for clinical evaluation of Level of C - Reactive protein in Stable COPD Patients from Bihar Region. The present study was planned in Department of General Medicine, Patna Medical College and Hospital, Patna, Bihar. The study was done from Nov 2015 to Dec 2016. Total 50 patients were included in the present study. Out of that 25 cases of COPD were enrolled in study group and 25 cases of the normal patients were enrolled as control cases. The diagnosis of COPD was based on pulmonary function tests which were performed according to American Thoracic Society guidelines and COPD was defined on the basis of post bronchodilator FEV1/FVC ratio of less than 0.70 and FEV1< 80%. Patients were staged based on FEV1/FVC ratio according to GOLD stage I-IV. Our study confirms that C-reactive protein levels are higher in COPD patients. So C-reactive protein levels indirectly reflect exercise capacity of stable COPD patients. Thus we conclude that measurement of C-reactive protein levels may be a useful tool to predict the prognosis and patient outcome in COPD patients.