Vol. 5, Issue 11 (2019)
Clinical significance of the levels of HbA1C and vitamin D & B12 in tuberculosis patients with diabetes
Author(s): Dr. Arohi Kumar
Abstract: There have been studies on establishing association between Vit D status and insulin secretion and insulin sensitivity with differing results in various ethnic populations. Many have studied the effect of Vit D supplementation on T2DM again with differing results. With Vitamin D deficiency prevailing in epidemic proportions all over the Indian subcontinent and with a phenomenal prevalence of 70%–100% in the general population, we thought it was important to elucidate the status of vitamin D and its possible relation with insulin resistance in Type 2 DM. Hence based on the above reported findings the present study was planned to study clinical significance of the levels of hba1c and vitamin D & B12 in tuberculosis patients with diabetes. The present study was planned in Narayan Medical College and Hospital, Jamuhar Sasaram, Bihar, India. Total 100 patients referred to Department of General Medicine were enrolled in the present study. The 50 cases of the diabetes diagnosed with the tuberculosis were evaluated as cases and 50 cases of the normal cases were evaluated as a control cases. Serum levels of vitamin B-12 were measured by electrochemi-luminescence immunoassay. Levels of 25-hydroxy vitamin D3 [25(OH) D3] were measured by radioimmunoassay (RIA). Levels of HbA1c were measured by high-performance liquid chromatography (HPLC). Blood pressure, height, body weight, and waist and hip circumferences of each patient were measured as an anthropometric and dietary measurement. Body mass index (BMI) and ratios of waist to hip circumference was calculated. Blood pressure of each patient was measured after giving rest for at least 5 min. The data generated from the present study concludes that the levels of the HbA1C were increases in Diabetes patients with TB whereas the levels of the Vitamin D and Vitamin B12 were decreases in diabetic patients with TB.
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