Vol. 5, Issue 2 (2019)
Assessment of the cases of neonatal septicemia with respect to antibiotic susceptibility pattern of isolates from Bihar region
Author(s): Dr. Deepak Kumar, Dr. K. K Sinha
Abstract: Neonatal sepsis refers to systemic and generalized bacterial infection of the new born documented by a positive blood culture in the first four weeks of life and is one of the four leading causes of neonatal mortality in India. The gold standard for diagnosis of septicemia is the isolation of bacterial agent from blood culture. The prevalence of bacterial profile of blood culture and their susceptibility patterns in an area, provide guidance to start empirical treatment which is the cornerstone in the management of sepsis. Hence present study was planned to evaluate the neonatal septicemia and antibiotic susceptibility pattern of isolates in Bihar region. The present study was planned in Jawaharlal Nehru Medical College Bhagalpur, Bihar, India. The study was conducted from July 2015 to Jun 2016. Out of the total 477 cases admitted to our hospital 20 cases were found positive for the Neonatal Septicemia. A detailed history of age, sex, birth weight, gestational age, and clinical symptoms of septicemia was recorded. Neonatal sepsis were suspected when any of the signs and symptoms or predisposing factors such as reduced activity, fever, refusal of feed, seizures, prolonged jaundice, birth asphyxia, umbilical sepsis, prematurity were noted in the new born. Gram negative bacteria were more commonly the cause of septicemia in neonates, and Klebsiella pneumoniae was the predominant pathogen. We also noticed that these Gram negative bacteria were resistant to routinely used antibiotics, hence their resistant pattern should be considered essential before deciding the empirical treatment. There is a need to implement Antimicrobial stewardship programmes to rationalise antibiotic usage to reduce neonatal mortality due to sepsis. Early detection of sepsis and judicial use of antibiotics are useful to decrease neonatal mortality and the emergence of multidrug resistant bacteria.