Vol. 5, Issue 3 (2019)
Assessment of dermatological lesions in HIV reactive patients: A Histopathogical Evaluation
Author(s): Dr. Ajay Kumar, Dr. Ashok Prasad, Dr. Subrata Chakraborty
Abstract: The possibility of adverse drug reaction should always be included in the differential diagnosis of any inflammatory dermatomes in HIV positive patients. Drugs may give rise to variety of histological patterns e.g. lichinoid, spongiotic, pustular, vesiculobullous and urticarial reaction. There are only few such reports from India. Therefore, this study was conducted to determine the pattern of histopathogical study of dermatological lesions in HIV reactive patients. The study was planned on 20 patients in the Department of Pathology in Mata Gujri Memorial Medical College & Lions Seva Kendra Hospital Kishanganj, Bihar from Aug 2017 to July 2018. The patients found HIV positive and observed with the dermatological legions were enrolled in the present study. All the patients were screened for mucocutaneous disorders by an experienced dermatologist. The clinical diagnosis was confirmed with laboratory procedures like microscopy (KOH preparations, Tzanck smear) and histopathological evaluation whenever necessary. Skin diseases were more common in males than females. There is a change in spectrum of skin diseases seen previously – maybe because of environmental issues such as global warming or depletion of ozone layer or use of chemicals. Histopathological correlation is therefore pivotal in the accurate diagnosis of many HIV induced skin diseases. The histopathological examination of such lesions helps in confirming the diagnosis as they have high sensitivity and specificity values.