Vol. 5, Issue 3 (2019)
Correlation of zinc levels to oxidative status in idiopathic chronic pancreatitis
Author(s): Dr. Rakesh Kumar Singh, Dr. Sanjay Kumar, Dr. Manish Mandal, Dr. Ravi Shekhar
Abstract: Background: Causative factor of chronic pancreatitis is unknown. Idiopathic Chronic pancreatitis is especially prevalent in India. Among multiple factors, Oxidative stress induced free radicals is one implicated factor in perpetuating the pancreatic inflammation and progression of chronic pancreatitis. Aim: Present study was planned to assess the oxidative status in Idiopathic Chronic Pancreatitis and its relation with Zinc status. Methods: 49 patients were enrolled in the present study over 3 year (From December 2015 to December 2018). 49 healthy subjects were also enrolled from their relatives as control. Demographic data, disease characteristics and imaging features were recorded. Erythrocyte glutathione, Glutathione peroxidise, Superoxide dismutase, erythrocyte Zinc level and plasma Vitamin C level were estimated by spectrophotometry. Results: Reduced erythrocyte Zinc level and plasma Vitamin C level were observed in chronic pancreatitis. Reduced antioxidant status was also found in chronic pancreatitis. The erythrocyte Zinc level significantly correlated with SOD activity. Conclusions: The present study found a positive correlation between erythrocyte zinc and erythrocyte SOD activity. This suggests that zinc deficiency may play a role in aggravating oxidative stress in CP and is another possible mechanism by which zinc deficiency impacts the pathogenesis of CP and its complications. But the clinical benefits of zinc supplementation in Idiopathic chronic pancreatitis, can be better elucidated by further study.
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