Vol. 5, Issue 5 (2019)
Effect of pregabalin premedication on the dose of dexmedetomidine infusion for induced hypotension in functional endoscopic sinus surgery
Author(s): Dr. Bibha Kumari, Dr. Shashi Kant, Dr. Rajnish Kumar
Abstract: Functional Endoscopic Sinus Surgery (FESS) requires dry surgical area in order for the surgeon to recognize the structure accurately as the anatomical structure of the surrounding area is complicated and the surgical site is near to the eye, brain, cranial base, important vessels and nerves. Excess bleeding leads to defective visibility and causes major complications during FESS. Dry surgical area can be produce by controlled hypotension techniques. Pregabalin are GABA pentanoids when given orally, its peak in plasma reaches within 1 hour. In this study we estimate the effect of pregabalin on celebrate hypotension surgical site quality during FESS, Intraoperative infusion dose of dexmedetomidine. and recovery time from anaesthesia. The objective of my study was to contemplate the effect of pregabalin premedication on the dosage of dexmedetomidine. Primary end point of the study is overall dose of dexmedetomidine and the recovery time in minutes. Secondary end points are the Intraoperative hemodynamic parameters. The present study was planned in the Department of Anaesthesiology and Critical Care, Indira Gandhi Institute of Medical Sciences, Patna. 50 patients scheduled for elective FESS, were randomized in two groups with 25 patients in each group. Group C is the Control group received placebo capsule (similar to pregabalin) 1 hour before surgery and Group P is Pregabalin group received Pregabalin 150 mg capsule orally 1 hour before surgery. The data generated from the present study concludes that by the use of oral Pregabalin there is decrease in the total dose of Dexmedetomidine improvement in the quality of the surgical site during FESS, and also there is decrease in post-operative recovery time. Also dexmedetomidine offers the advantage of inherent analgesic, sedative and aesthetic sparing effect.