Causative agents of neonatal sepsis: A study in Tertiary Care Paediatric Hospital, Dhaka, Bangladesh
Md. Kamruzzaman, Md. Mosharaf Hossain, Mohammad Nazmul Hasan Chowdhary, Probir Kumar Sarkar, Sarabon Tahura
Sepsis means the presence of bacteria (bacteremia), other infectious organisms, or toxins created by infectious organisms in the bloodstream with spread throughout the body. Neonatal sepsis is an invasive infection, usually bacterial, occurring during the neonatal period. Signs are multiple, nonspecific, and including diminished spontaneous activity, less vigorous sucking, apnea, bradycardia, temperature instability, respiratory distress, vomiting, diarrhea, abdominal distention, jitteriness, seizures, and jaundice. The aim of this study was to evaluate the causative agents of neonatal septicemia in the children admitted to the Department of Paediatrics of Dhaka Shishu (children) Hospital, Dhaka, Bangladesh during the period from January 2017 to December 2017. The study was planned by enrolling 176 neonates admitted in the selected hospital. The 50 neonates diagnosed with the septicemia were enrolled. In the study; most of the mothers were 20-30 years age group, representing 45%. Most of them were completed higher secondary education, representing 52.50%. Socio-economic classes lower representing 55% of the study participants. Regarding parity; 67.50% of the study participants were parity one (1). Only 32.50% mothers taken antenatal care more than 3 times. Predisposing factors were negative in more than 80% of mothers and most of modes of delivery were 60% of mothers. Late Onset Sepsis was 65% of babies and Gram positive were 25% of the patients. In this study, the most common bacteria found associated with neonatal sepsis in the inborn unit was Klebsiella (45%) followed by Acinetobacter 17.50%, Citrobacter 7.50% and Pseudomonas 2.50%. The data from the present study revealed that, there is need to undertake research to understand the pathogenesis of early-onset sepsis and to devise measures to prevent related morbidity and mortality. To improve the survival rate, better approach is to take early initiation of appropriate antibiotics and aggressive supportive care based on local sensitivity pattern and fatal risk factors.