A study on efficacy of aceclofenac versus aceclofenac plus pregabalin in management of nonspecific chronic low back pain
K Yashas Sree, B Mounica, L Chandini Devi, K Divya Vani, Dr. M Pratibha, Dr. M Sudhakar
Chronic low back pain (CLBP) has been associated with neurochemical, structural, and functional cortical changes of several brain regions including the somatosensory cortex. Complex processes of peripheral and central sensitization may influence the evolution of acute to chronic pain. It is a common disorder involving the muscles, nerves, and bones of the back. Low back pain may be classified by duration as acute (pain lasting less than 6 weeks), sub-acute (6 to 12 weeks), or chronic (more than 12 weeks). In most episodes of low back pain, a specific underlying cause is not identified. Aceclofenac is a Non-Steroidal Anti-Inflammatory Drug (NSAID). It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling). Pregabalin is an Anticonvulsant Drug Used For Neuropathic Pain, epilepsy and generalized anxiety disorder. It presents antihyperalgesic actions by binding to the α2δ subunit of the voltage-dependent calcium channels without presenting antinociceptive actions. Aim: To study the efficacy of Aceclofenac vs Aceclofenac plus Pregabalin in patients with chronic low back pain Objectives § To compare and evaluate the therapeutic effectiveness of aceclofenac and aceclofenac plus pregabalin in relieving chronic low back pain § To identify and apply strategies to prevent the increase of pain § To provide patient counseling in the betterment of patients quality of life and provide awareness towards medication adherence. Materials and methods: In this study, aceclofenac as a single and aceclofenac with pregabalin as a combinational regimen were randomly received by 105 patients for 14 days. Patient’s pain was assessed using VAS scale (visual analogue scale) on day 1,7,14. Results: When patients were pooled according to VAS scale Aceclofenac and Aceclofenac plus Pregabalin were effective in reducing non specific chronic low back pain. The combination therapy showed more effectiveness when compared to single/ monotherapy when patients were taken according to VAS. Conclusion: Aceclofenac plus Pregabalin combination is more effective than monotherapy with Aceclofenac for non specific chronic low back pain. Combination showed quicker relief of pain when compared to monotherapy.