Seroprevalence of hepatitis e in patients with chronic liver disease: A study in Dhaka Shishu (children) hospital, Dhaka, Bangladesh
Dr. Ahmed Rashidul Hasan, Dr. Salahuddin Mahmud, Kamrun Nahar, Dr. Emdadul Haque, Dr. AKM Khairul Islam
Introduction: Super infection with HEV in patients with chronic liver disease (CLD) can cause severe hepatic decompensation leading to increased morbidity and mortality. This study aimed to determine seroprevalence of HEV infection among CLD patients compared to blood donors from Bangladesh. Methods: CLD patients and a bunch ancient matched blood donors with traditional liver perform tests were evaluated for the presence of anti-HEV immune gamma globulin protein in their sera for proof of liver disease E. The risk factors were estimated. Results: The mean age of CLD patients was 18 years (range: 1-18). 27.5% of patients were HEV IgG-positive. Among the controls 19.7% were positive for anti-HEV IgG. By multivariate analysis, there was no association between positive anti-HEV IgG and etiology of chronic liver disease, gender, literacy, accommodation, and number of family members in patients or controls. Mean age of patients infected with HEV in both groups was significantly more than the seronegative ones. Conclusions: We found high seroprevalence of HEV-antibody among blood donors and CLD patients in our study, so we recommend more attention to hygiene of food and water. In addition, such patients should be informed about the potential risks and simple ways to prevent the disease in their regular life and travels. This issue must be concerned in cases of "acute on chronic" hepatitis in CLD patients.